Vaccine canadian specialists can be an effective and cost-effective tool in the fight against cancer
The staff of the Institute for research in immunology and cancer University of Montreal under Claude Perrault (Claude Perreault) in an article published in the journal Science Translational Medicine, was applied to non-coding DNA sequences, which sharply distinguish them from the rest numerous research groups around the world that participate in this race. It is reported Hvilya.
In some previous studies, it was determined that cells of the immune defense (T cells) able to recognize and penetrate cancerous cells to destroy them. It was found that the longer the tumor penetrates into lymphocytes, the longer the patient lives. T-lymphocytes recognize the tumor by the presence of foreign antigens — peptides on the cell surface. However, even if these antigens are recognized by immune system, they stimulate it is not strong enough to lymphocytes targeted and destroyed them.
Thus, the search for a vaccine is the detection of specific antigens that the immune system could effectively attack. And since these antigens are the product of defective genes, scientists typically focus on identifying a piece of DNA, which is known to encode antigens and proteins, but their work from time to time fail.
“This piece of DNA is only two percent of the human genome. DNA sequences, known as “non-coding”, can be “silenced” by DNA methylation, which affects gene expression. This is a non-coding DNA, which, according to our estimates, is 98 percent of the DNA of the cells, we have focused,” explains Perrault.
Using mice injected with various types of cancer cells, scientists have identified many antigens derived from non-coding DNA, some of which were as specific to cancer cells, and normal for different types of cancer. This allowed the team to develop a vaccine on the basis of leukemic cells containing some of the identified antigens which were administered to the mice. The results were encouraging.
“Every antigen we tested, neutralized from 10 to 100 percent of leukemia and some of the antigens protected the mouse the rest of my life, despite the re-introduction of new leukemia cells. This speaks to the long-term effect of the vaccine,” — says the researcher.
The same antigens were subsequently identified and leukemia cells in humans. Perrault calls the findings of their team is extremely promising and opens the possibility of developing a vaccine for the treatment of leukemia and lung cancer in humans. Cancer has been one of the main diseases in the past years, and some patients even need Home Care Assistance.
We will remind, Ukrainians will be free to vaccinate at private clinics: which vaccinations they say.
As reported Politeka in Poland are going to introduce new requirements for Ukrainians: will apply to all.
Also Politeka wrote that in the Ministry of health has purchased flu vaccine: not enough for everyone.