Scientists have discovered how to reduce the impact of bad cholesterol on the liver
Scientists were able to prove that olive oil is beneficial to lovers fat food and good for your liver.
The results of one of them showed that due to special compounds in the composition of olive oil can compensate for the harm of fatty foods. A team of specialists under the guidance of Dr. Rodrigo Valenzuela of the University of Chile took up the study of the effects of this oil on the health of experimental mice.
Researchers believe that the beneficial effects of olive oil are largely due to part of it with hydroxytyrosol, a polyphenol known for its antioxidant properties. In the new work has also been shown that this compound possesses hepatoprotective effects. The results of a study published in Lipids in Health and Disease.
Dr. Valenzuela and his colleagues studied the effect of hydroxytyrosol on mice fed a fatty food. Scientists drew attention to the special enzymes that play a key role in the synthesis of polyunsaturated fatty acids. They are able to lower “bad” cholesterol, furthermore, they positively influence the condition of cardiovascular system, brain function and cell growth.
Experts have divided the laboratory mice into 4 groups of 12-14 each. Mouse from the first two groups received food with 60 percent fat content. In the feed for 3-th and 4-th group, the fat content was only 10%. In addition, part of the mice were given hydroxytyrosol 5 mg / kg of body weight per day for 12 weeks.
At the end of the experiment revealed that mice fed a diet with high fat content, and increased as total cholesterol and levels of low-density lipoprotein (“bad” cholesterol). The level of high-density lipoproteins (“good” cholesterol) did not change. However, on a background of reception of hydroxytyrosol negative impact of cholesterol on the health status of the mice decreased.
Liver mice fed fatty food, began to produce less of the enzymes required for the synthesis of useful polyunsaturated fatty acids. The imbalance of fatty acids were detected in liver, brain and heart of mouse. In fact, began in experimental non-alcoholic fatty liver disease. Ketogenic diet has led to increased level of oxidative stress in the liver.
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But mice fed and high fat diet, and hydroxytyrosol, the activity of liver enzymes was at the same level as in animals from the control group. Therefore, the researchers concluded that relatively small doses can reverse the damage that fatty food causes the liver.
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