How to stop a disease that kills children: the response of scientists

Как остановить болезнь, которая "убивает" детей: ответ ученых

Early death occurs because of a mutation in a gene, resulting in stops the development of important muscles

American scientists from Florida and California universities found that improves heart function and prevents early death from Duchenne muscular dystrophy.

Note, this disease is caused by mutations in the gene encoding the protein dystrophin. The latter plays an important role in the reduction and development of cardiac, respiratory and skeletal muscles.

With age increases the risk of heart failure, although some treatments help to prevent muscle degradation. However, unfortunately, young patients with a terrible disease Duchenne often live only 20-30 years.

Как остановить болезнь, которая "убивает" детей: ответ ученых

During the study, the researchers came to the conclusion that the fatal genetic disease can be stopped using protein sarcospan. The latter is not a full substitute for dystrophin, but intense gene expression stabilizes cell membranes, improving contractile function. Such a connection helps with stress.

Sarcospan can do coverage for other membrane proteins, allowing a small existing part of dystrophin to maintain the fragile membrane of cardiac proteins.

We will remind, some years the Swedish scientists measured the pulse rate in men. The results showed, if being in the resting male heart rate is 75 beats per minute, it may indicate premature death.

Как остановить болезнь, которая "убивает" детей: ответ ученых

This study involved 798 volunteers, born in 1943 in the Swedish city of Gothenburg. During the survey each of the men filled lines about the way of life, level of stress and questions about cardiovascular diseases to your family.

In addition, all were medpower, after which the men were divided into 4 groups: 55 beats per minute or less, 55-65, 65-75, and over 75 beats.

During the experiment it became known — a man with a heart rate above 55 led a sedentary lifestyle and Smoking. And in the group with heart rate above 75 are twice as likely to die from cardiovascular disease and other causes than in the group with strokes less than 55 strokes per minute.

Thus, it has become clear who are most at risk of premature death.

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